Psilocybin Unveiled: What happens to the brain and body on psilocybin?

Psilocybin, the key psychoactive compound found in certain species of mushrooms and truffles, has captured the attention of scientists, researchers, and enthusiasts alike. Psilocybin has a rich historical and cultural significance spanning numerous societies around the world.

For centuries, various cultures have recognized the mystical and transformative properties of magic mushrooms. From ancient indigenous rituals to modern-day spiritual practices, these mushrooms have been used for their profound effects on consciousness and perception.

In indigenous cultures, such as those in Central and South America, magic mushrooms have been integral to shamanic ceremonies and spiritual traditions. The mushrooms were regarded as a conduit to connect with the divine, facilitating spiritual growth, healing, and insights into the nature of existence.

Beyond their spiritual and cultural significance, psilocybin has gained increasing attention in scientific research and clinical settings. Recent studies have demonstrated their potential therapeutic applications in addressing mental health conditions like depression, anxiety, and addiction.

It's important to note that the use of psilocybin is not without controversy and legal restrictions exist in many countries. However, shifting attitudes and growing scientific evidence are prompting a reevaluation of these substances, leading to discussions on decriminalization and medical legalization in certain regions.


By exploring the effects of psilocybin on the body and brain, we can gain a deeper understanding of its potential benefits and risks. In this article, we break down what happens when you take psilocybin, from the moment of consumption to after the ingestion.

Stage 1: Psilocybin enters the body

When you consume psilocybin, your body converts it into a compound called psilocin. Imagine psilocybin as a seed, and psilocin as the blooming flower that grows from that seed, displaying its vibrant colors and fragrance.

Psilocin is the active substance that affects your brain and body, leading to psychedelic experiences.


Stage 2: When psilocin gets to the brain


Psilocin interacts with serotonin 2A receptors in the brain. Imagine the serotonin 2A receptors as doorways in your brain, and psilocin acts as a key that unlocks and opens those doors.


  • Serotonin is a chemical messenger that regulates mood, emotions, and perception.


  • Psilocin binds to serotonin 2A receptors, influencing serotonin signaling pathways.


  • This binding and activation of receptors lead to changes in perception and mood.


Stage 3: What psilocin does in the brain

Psilocybin affects how different brain regions communicate with each other. Imagine your brain as a network of roads connecting different cities. Normally, certain brain regions have limited communication with each other, like separate cities with no direct routes. However, when psilocybin is introduced, it's like a sudden surge of traffic on the brain's highways. Brain regions that usually operate independently start communicating and sharing information more extensively.


  • Using brain imaging techniques like fMRI, studies have shown increased connectivity between brain regions that are usually separate.


  • Psilocybin enhances connectivity in networks like the default mode network and the visual cortex.


  • The default mode network is associated with introspection and self-reflection, while the visual cortex processes visual information


  • The increased connectivity between these networks is believed to contribute to hallucinatory experiences and changes in mental states.


The Conclusion

In conclusion, the journey into the world of psilocybin reveals a fascinating interplay between the compound and the brain. From its historical and cultural significance to its potential therapeutic applications, psilocybin continues to captivate the interest of researchers and explorers alike.


When psilocybin enters the body, it undergoes a transformation, converting into psilocin, the active substance responsible for the psychedelic experience. Psilocin then interacts with serotonin 2A receptors in the brain, acting as a key that unlocks new pathways of perception and mood.


The effects of psilocybin on the brain are profound. It enhances neural connectivity, allowing different brain regions to communicate more extensively, like a surge of traffic on the brain's highways. This increased connectivity, particularly in networks like the default mode network and the visual cortex, contributes to hallucinatory experiences and altered mental states.